来那度胺杂质 99
4-Aminophthalide
CAS: 59434-19-4
Molecular Formula: C8H7NO2
来那度胺杂质 99 - Names and Identifiers
| Name | 4-Aminophthalide |
| Synonyms | 4-Aminophthalide Lenalidomide Impurity 99 4-Amino-3H-isobenzofuran-1-one 4-Amino-2-benzofuran-1(3H)-one 4-aMinoisobenzofuran-1(3H)-one 4-Amino-3H-isobenzofuran-1-one 1(3H)-Isobenzofuranone, 4-amino- |
| CAS | 59434-19-4 |
| InChI | InChI=1/C8H7NO2/c9-7-3-1-2-5-6(7)4-11-8(5)10/h1-3H,4,9H2 |
来那度胺杂质 99 - Physico-chemical Properties
| Molecular Formula | C8H7NO2 |
| Molar Mass | 149.15 |
| Density | 1.376 |
| Melting Point | 154-155 °C |
| Boling Point | 411.0±45.0 °C(Predicted) |
| Flash Point | 241.528°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 2.70±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.656 |
来那度胺杂质 99 - Introduction
4-Aminophthalide(4-Aminophthalide) is an organic compound with the chemical formula C8H7NO2. It is a white crystalline solid with a peculiar smell. The following is an introduction to its nature, use, preparation and safety information:
Nature:
4-Aminophthalide is a white crystalline solid at room temperature with a high melting point, soluble in organic solvents such as alcohols, ethers and ketones, and slightly soluble in water. It can undergo coloring changes through oxidation and reduction reactions.
Use:
4-Aminophthalide is an important organic synthesis intermediate for the synthesis of sulfasalamide (Lumazine) and aminophthalide (Phthalanil). In addition, it can also be used for the preparation of dyes and fluorescent substances.
Preparation Method:
4-Aminophthalide can be obtained by heating terephthalic anhydride (phthalic anhydride) in ammonia. The reaction conditions were as follows: Terephthalic anhydride was dissolved in ammonia and the reaction mixture was heated to give 4-Aminophthalide.
Safety Information:
4-Aminophthalide has certain safety hazards. It is an irritating substance that may irritate the eyes and skin. Wear appropriate protective gloves, eye and breathing apparatus during handling. If contact with skin or eyes, rinse immediately with plenty of water and seek medical help. At the same time, avoid inhaling its vapor or dust and maintain a well-ventilated working environment. It is recommended to follow the normal storage and use precautions of chemicals. During use, special attention should be paid to personal protective measures and relevant regulations should be observed.
Nature:
4-Aminophthalide is a white crystalline solid at room temperature with a high melting point, soluble in organic solvents such as alcohols, ethers and ketones, and slightly soluble in water. It can undergo coloring changes through oxidation and reduction reactions.
Use:
4-Aminophthalide is an important organic synthesis intermediate for the synthesis of sulfasalamide (Lumazine) and aminophthalide (Phthalanil). In addition, it can also be used for the preparation of dyes and fluorescent substances.
Preparation Method:
4-Aminophthalide can be obtained by heating terephthalic anhydride (phthalic anhydride) in ammonia. The reaction conditions were as follows: Terephthalic anhydride was dissolved in ammonia and the reaction mixture was heated to give 4-Aminophthalide.
Safety Information:
4-Aminophthalide has certain safety hazards. It is an irritating substance that may irritate the eyes and skin. Wear appropriate protective gloves, eye and breathing apparatus during handling. If contact with skin or eyes, rinse immediately with plenty of water and seek medical help. At the same time, avoid inhaling its vapor or dust and maintain a well-ventilated working environment. It is recommended to follow the normal storage and use precautions of chemicals. During use, special attention should be paid to personal protective measures and relevant regulations should be observed.
Last Update：2024-04-10 22:29:15
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CAS: 59434-19-4
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CAS: 59434-19-4
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View History
来那度胺杂质 99
TRANS-O-CUMARIC ACID
HEPTYL METHYL KETONE
Carbamic acid, [1-formyl-2-(methylthio)ethyl]-, methyl ester (9CI)
2-(2-ISOPROPYL-PHENOXY)-2-METHYL-PROPIONIC ACID
4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL) BENZENESULFONAMIDE
N-(6-氨基-1,3-苯并噻唑-2-基)丁烷酰胺
3-PHENYL-2-(1H-TETRAZOL-1-YL)PROPANOIC ACID
2-PHENYLHYDROACRYLIC ACID
C.I. Oxidation Base 21
TRANS-O-CUMARIC ACID
HEPTYL METHYL KETONE
Carbamic acid, [1-formyl-2-(methylthio)ethyl]-, methyl ester (9CI)
2-(2-ISOPROPYL-PHENOXY)-2-METHYL-PROPIONIC ACID
4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL) BENZENESULFONAMIDE
N-(6-氨基-1,3-苯并噻唑-2-基)丁烷酰胺
3-PHENYL-2-(1H-TETRAZOL-1-YL)PROPANOIC ACID
2-PHENYLHYDROACRYLIC ACID
C.I. Oxidation Base 21